Distinction, a WordPress theme by James Laws gives each piece of content a distinct look and feel. It is customizable with custom menus, backgrounds, and utilizes post formats to give content a little extra flare.
Distinction supports six widgetized areas (two in the sidebar, four in the footer). It includes stylesheets for print, special styles for post formats, and has an optional one-column page template that removes the sidebar.
Theme homepage; http://themes.wpninjas.net/distinction/