BackupBuddy is an all-in-one solution for backups, restoration, and migration. Back up to your server, Amazon S3, a FTP/FTPS account, or an email. Use the backup with the Importing & Migrating script to quickly and easily restore your site on the same server or even migrate to a new server with a different domain and database.
Plugin homepage: http://pluginbuddy.com/purchase/backupbuddy/